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. 1979;6(5):1869–1879. doi: 10.1093/nar/6.5.1869

Antibiotic induced electrophoretic mobility shifts of DNA restriction fragments.

E Loucks, G Chaconas, R W Blakesley, R D Wells, J H van de Sande
PMCID: PMC327817  PMID: 450716

Abstract

Several antibiotics, netropsin, distamycin A, actinomycin D, Hoechst 33258 and olivomycin, which demonstrate base specificity in their DNA binding properties have been found to alter the electrophoretic mobility of DNA restriction fragments in native polyacrylamide gels. The antibiotics mostly reduced the migration of larger DNA fragments, but netropsin and Hoechst 33258 were observed to increase the migration rate of several DNA fragments of intermediate size. DNA fragments of similar molecular weight which comigrate as a single gel band can at times be separated as the result of differential mobility shifts promoted by antibiotic DNA complex formations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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