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. 1979 Jun 11;6(7):2569–2582. doi: 10.1093/nar/6.7.2569

Rapid chemical synthesis and circular dichroism properties of some 2'-5'-linked oligoriboadenylates.

A F Markham, R A Porter, M J Gait, R C Sheppard, I M Kerr
PMCID: PMC327872  PMID: 379823

Abstract

Specific synthesis of some oligoadenylates including A2'p5'A2'p5'Ap(2'), the 2'-phosphorylated oligoribonucleotide core of the recently discovered protein synthesis inhibitor pppA2'p5'A2'p5'A is described using a novel solid-phase method. The CD spectra of A2'p5'Ap(2'), A2'p5'A2'p5'Ap(2') and A2'p5'A2'p5'A (derived by treatment of the phosphorylated synthetic trimer with E. coli alkaline phosphatase) are presented. Comparison of the latter spectrum with that of A2'p5'A2'p5'A obtained similarly from a biologically derived sample of pppA2'p5'A2'p5'A provides further evidence that this molecule is in fact the first naturally-occurring 2'-5'-linked oligoribonucleotide.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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