Skip to main content
PMC home page
Nucleic Acids Research logoLink to Nucleic Acids Research
. 1979 Jul 11;6(9):3093–3118. doi: 10.1093/nar/6.9.3093

Interaction of DNA with a porphyrin ligand: evidence for intercalation.

R J Fiel, J C Howard, E H Mark, N Datta Gupta
PMCID: PMC327919  PMID: 573891

Abstract

The porphyrin photosensitizer, meso-Tetra (4-N-methylpyridyl) porphine tetraperchlorate binds to calf thymus DNA by intercalation and by external electrostatic association. This was concluded from the results of measruements involving Scatchard analysis, viscometry, thermal denaturation, and circular dichroism.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson C. F., Record M. T., Jr, Hart P. A. Sodium-23 NMR studies of cation-DNA interactions. Biophys Chem. 1978 Jan;7(4):301–316. doi: 10.1016/0301-4622(78)85007-8. [DOI] [PubMed] [Google Scholar]
  2. Bontemps J., Fredericq E. Comparative binding study of the interaction of quinacrine and ethidium bromide with DNA and nucleohistone. Biophys Chem. 1974 Jun;2(1):1–22. doi: 10.1016/0301-4622(74)80019-0. [DOI] [PubMed] [Google Scholar]
  3. Dougherty T. J., Grindey G. B., Fiel R., Weishaupt K. R., Boyle D. G. Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light. J Natl Cancer Inst. 1975 Jul;55(1):115–121. doi: 10.1093/jnci/55.1.115. [DOI] [PubMed] [Google Scholar]
  4. Fiel R. J., Mark E. H., Gupta N. D. Radiation modifying effects of meso-tetraphenyl porphyrins. Res Commun Chem Pathol Pharmacol. 1975 Jan;10(1):65–76. [PubMed] [Google Scholar]
  5. Krey A. K., Hahn F. E. Studies on the Methyl Green-DNA complex and its dissociation by drugs. Biochemistry. 1975 Nov 18;14(23):5061–5067. doi: 10.1021/bi00694a005. [DOI] [PubMed] [Google Scholar]
  6. Levine H. I., Fiel R. J., Billmeyer F. W., Jr Very low-angle light scattering. A caharacterization method for high-molecular weight DNA. Biopolymers. 1976 Jul;15(7):1267–1281. doi: 10.1002/bip.1976.360150705. [DOI] [PubMed] [Google Scholar]
  7. Li H. J., Crothers D. M. Relaxation studies of the proflavine-DNA complex: the kinetics of an intercalation reaction. J Mol Biol. 1969 Feb 14;39(3):461–477. doi: 10.1016/0022-2836(69)90138-7. [DOI] [PubMed] [Google Scholar]
  8. McGhee J. D., von Hippel P. H. Formaldehyde as a probe of DNA structure. I. Reaction with exocyclic amino groups of DNA bases. Biochemistry. 1975 Mar 25;14(6):1281–1296. doi: 10.1021/bi00677a029. [DOI] [PubMed] [Google Scholar]
  9. Müller W., Crothers D. M. Studies of the binding of actinomycin and related compounds to DNA. J Mol Biol. 1968 Jul 28;35(2):251–290. doi: 10.1016/s0022-2836(68)80024-5. [DOI] [PubMed] [Google Scholar]
  10. Pasternack R. F. Aggregation of properties of water-soluble porphyrins. Ann N Y Acad Sci. 1973;206:614–630. doi: 10.1111/j.1749-6632.1973.tb43240.x. [DOI] [PubMed] [Google Scholar]
  11. Sakore T. D., Jain S. C., Tsai C. C., Sobell H. M. Mutagen-nucleic acid intercalative binding: structure of a 9-aminoacridine: 5-iodocytidylyl(3'-5')guanosine crystalline complex. Proc Natl Acad Sci U S A. 1977 Jan;74(1):188–192. doi: 10.1073/pnas.74.1.188. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sobell H. M., Reddy B. S., Bhandary K. K., Jain S. C., Sakore T. D., Seshadri T. P. Conformational flexibility in DNA structure as revealed by structural studies of drug intercalation and its broader implications in understanding the organization of DNA in chromatin. Cold Spring Harb Symp Quant Biol. 1978;42(Pt 1):87–102. doi: 10.1101/sqb.1978.042.01.010. [DOI] [PubMed] [Google Scholar]
  13. Sobell H. M., Tsai C. C., Jain S. C., Gilbert S. G. Visualization of drug-nucleic acid interactions at atomic resolution. III. Unifying structural concepts in understanding drug-DNA interactions and their broader implications in understanding protein-DNA interactions. J Mol Biol. 1977 Aug 15;114(3):333–365. doi: 10.1016/0022-2836(77)90254-6. [DOI] [PubMed] [Google Scholar]
  14. Waring M. J., Henley S. M. Stereochemical aspects of the interaction between steroidal diamines and DNA. Nucleic Acids Res. 1975 Apr;2(4):567–586. doi: 10.1093/nar/2.4.567. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press

RESOURCES