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Greater inflammation in Hsd11b1−/− mice during carrageenan-induced pleurisy. Pleurisy was induced in Hsd11b1−/− (white bars) and control (black bars) mice by intrapleural injection of 100 μl 0.1% carrageenan. Four, 24, and 48 h later, cells were lavaged (with 1 ml PBS) and counted. Results are mean ± sd, expressed as cells per milliliter (n = 7/group); **, P < 0.01 by two-way ANOVA.
