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. 1980 Dec 20;8(24):6213–6219. doi: 10.1093/nar/8.24.6213

Halogenation of tubercidin by N-halosuccinimides. A direct route to 5-bromotubercidin, a reversible inhibitor of RNA synthesis in eukaryotic cells.

D E Bergstrom, A J Brattesani
PMCID: PMC328083  PMID: 6162160

Abstract

Tubercidin may be directly brominated by reaction with N-bromosuccinimide in DMF to give 5-bromotubercidin, a reversible inhibitor of RNA synthesis. When buffered with potassium acetate the major product is 6-bromotubercidin. 5,6-Dibromotubercidin is formed in minor amounts under both conditions. N-Chlorosuccinimide and tubercidin give 5-chlorotubercidin and 5,6-dichlorotubercidin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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