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. 2012 Jan 17;153(3):1453–1463. doi: 10.1210/en.2011-1020

Fig. 2.

Fig. 2.

CYP3A7 protein level and its activity at different developmental days. A, Western blot analysis of pooled hepatic microsomes prepared from Tg3A4/7-hPXR mice detected using polyclonal antibody specific to human CYP3A7. B, CYP3A7 enzymatic activity as measured by the increase of 16α-OH DHEA and indicated by the decrease of DHEA, a relatively specific substrate of CYP3A7. Results are shown as the means ± sd of individual liver microsomes; n = 5. *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with mice born at E18.5. C, CYP3A7 enzymatic activity in Tg3A4/7-hPXR mice and wild-type mice at P2.5. Data are shown as mean ± sd of individual liver microsomes; n = 4. *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with Tg3A4/7-hPXR mice.