Table 2. Top 50 genes deregulated (FDR<0.1) in both mouse and human ATC, ranked by expression level in mouse.
| MouseGene | Hs1 ATC | Hs2 ATC | Mm ATC | MouseGene | Hs1 ATC | Hs2 ATC | Mm ATC |
|---|---|---|---|---|---|---|---|
| Upregulated | Downregulated | ||||||
| *Timp1 | 4.699 | 5.213 | 21.086 | Patz1 | 0.436 | 0.216 | 0.293 |
| *Steap1 | 3.760 | 14.778 | 10.021 | Suox | 0.729 | 0.297 | 0.291 |
| *Itga5 | 2.426 | 4.675 | 8.795 | Epb4.1l4b | 0.107 | 0.029 | 0.286 |
| Kif20a | 2.221 | 22.184 | 7.664 | Tnxb | 0.581 | 0.264 | 0.285 |
| Ccnb1 | 5.664 | 11.688 | 7.395 | Fxyd1 | 0.651 | 0.307 | 0.279 |
| Ccna2 | 3.119 | 14.546 | 7.167 | Grb14 | 0.748 | 0.342 | 0.276 |
| *Racgap1 | 7.247 | 15.876 | 6.938 | 1190002H23Rik | 0.252 | 0.212 | 0.274 |
| Rrm2 | 10.807 | 51.614 | 6.860 | Slc5a3 | 0.220 | 0.153 | 0.273 |
| *Prc1 | 5.295 | 26.946 | 6.491 | Wwc1 | 0.384 | 0.297 | 0.260 |
| *Tpx2 | 3.766 | 38.703 | 6.390 | Mettl7a1 | 0.090 | 0.050 | 0.257 |
| Kif4 | 3.613 | 19.001 | 5.861 | Stxbp6 | 0.373 | 0.044 | 0.254 |
| Cenpe | 2.001 | 13.520 | 5.749 | Tppp | 0.681 | 0.102 | 0.251 |
| Cep55 | 4.075 | 26.077 | 5.707 | Acacb | 0.527 | 0.069 | 0.242 |
| Kif2c | 2.029 | 9.175 | 5.374 | Bspry | 0.364 | 0.050 | 0.237 |
| Ccdc109b | 3.470 | 8.822 | 5.369 | Rbpms | 0.370 | 0.102 | 0.232 |
| Plau | 5.606 | 46.647 | 5.363 | Cds1 | 0.516 | 0.057 | 0.217 |
| Depdc1a | 1.771 | 7.384 | 5.303 | Nebl | 0.112 | 0.019 | 0.210 |
| Bub1b | 3.180 | 20.421 | 5.246 | Car4 | 0.273 | 0.053 | 0.203 |
| Basp1 | 3.274 | 8.466 | 5.114 | *Nkx2-1 | 0.147 | 0.016 | 0.200 |
| Asf1b | 1.904 | 4.015 | 4.831 | Pdk2 | 0.646 | 0.474 | 0.188 |
| Dtl | 3.446 | 5.716 | 4.782 | Bex1 | 0.178 | 0.025 | 0.182 |
| Tyrobp | 4.242 | 19.675 | 4.652 | Sorbs2 | 0.094 | 0.013 | 0.181 |
| Cdca8 | 1.837 | 6.322 | 4.577 | Cldn3 | 0.125 | 0.027 | 0.180 |
| Rcn1 | 3.697 | 2.780 | 4.547 | Sall1 | 0.287 | 0.018 | 0.180 |
| Cenpa | 1.714 | 3.183 | 4.503 | Prkcq | 0.432 | 0.134 | 0.180 |
| Foxm1 | 3.121 | 7.703 | 4.434 | *Duox2 | 0.107 | 0.015 | 0.178 |
| Nusap1 | 3.727 | 17.416 | 4.385 | Rragd | 0.222 | 0.163 | 0.174 |
| Dlgap5 | 2.449 | 22.229 | 4.359 | Smad9 | 0.691 | 0.024 | 0.173 |
| Gpsm2 | 2.351 | 2.026 | 4.339 | Fabp4 | 0.102 | 0.020 | 0.168 |
| C3ar1 | 2.891 | 15.589 | 4.170 | Pygm | 0.733 | 0.605 | 0.164 |
| Kntc1 | 1.534 | 7.468 | 4.146 | Gpr56 | 0.166 | 0.092 | 0.161 |
| Stil | 1.787 | 6.955 | 4.098 | Rap1gap | 0.143 | 0.028 | 0.157 |
| Ncaph | 1.652 | 4.310 | 4.088 | Erbb4 | 0.583 | 0.157 | 0.150 |
| Zwilch | 2.346 | 6.767 | 4.050 | Bex4 | 0.323 | 0.148 | 0.149 |
| Atad2 | 1.928 | 2.755 | 4.000 | Glb1l2 | 0.462 | 0.270 | 0.148 |
| Fabp5 | 7.508 | 4.293 | 3.954 | Ager | 0.683 | 0.392 | 0.144 |
| Cks2 | 9.287 | 26.933 | 3.911 | Lrp2 | 0.276 | 0.012 | 0.133 |
| Tubb6 | 4.194 | 4.191 | 3.839 | Ocln | 0.650 | 0.174 | 0.124 |
| Cdc20 | 5.251 | 35.621 | 3.822 | Myo5c | 0.181 | 0.046 | 0.112 |
| Melk | 5.470 | 15.689 | 3.765 | Bcam | 0.389 | 0.246 | 0.107 |
| Ttk | 3.254 | 22.640 | 3.702 | Fam13a | 0.304 | 0.124 | 0.094 |
| Aurkb | 1.639 | 2.222 | 3.661 | Id4 | 0.050 | 0.009 | 0.091 |
| Csf2rb | 2.201 | 22.256 | 3.632 | Fam189a2 | 0.170 | 0.015 | 0.083 |
| Cdkn3 | 4.688 | 16.665 | 3.625 | Cdh16 | 0.305 | 0.058 | 0.077 |
| Ube2c | 4.383 | 46.951 | 3.621 | *Ppargc1a | 0.362 | 0.055 | 0.069 |
| Fcgr2b | 2.191 | 15.069 | 3.561 | *Pax8 | 0.095 | 0.014 | 0.063 |
| Trip13 | 2.555 | 14.673 | 3.418 | *Tg | 0.011 | 0.001 | 0.061 |
| Ncapg2 | 2.384 | 7.484 | 3.407 | Kcnj16 | 0.034 | 0.003 | 0.045 |
| Mad2l1 | 5.281 | 15.378 | 3.398 | *Tshr | 0.029 | 0.005 | 0.045 |
| Mcm3 | 1.584 | 2.853 | 3.366 | *Tpo | 0.039 | 0.003 | 0.036 |