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. 2012 Feb 13;61(3):586–596. doi: 10.2337/db11-1091

FIG. 3.

FIG. 3.

Detection of 4-HNE, 3-nitrotyrosine, and nitrite in WKY and SHHF rat liver and skeletal muscle tissues. A: Red staining shows increased nitrotyrosine levels while green staining indicates elevated 4-HNE levels in the liver of SHHF rats with a great extent of colocalization. B: In comparison, only very mild changes were observed in the skeletal muscle. Confocal pictures are representative of six animals per group, three independent slides from each animal. C: Liver nitrite levels in SHHF rats showed a significant increase compared with WKY rats, while only slight, not significant changes were observed in skeletal muscle nitrite levels. Tissue samples were collected from three different animals and were run in triplicate on each sample. *P < 0.05 vs. control. (A high-quality digital representation of this figure is available in the online issue.)