FIG. 1.

Intravenous lipid infusion elevated FFA levels in both basal and hyperglycemic conditions. A: Timeline: mice with femoral artery and vein catheters received continuous intravenous 4-day infusions of 0.9% saline, Liposyn II, 50% glucose, or Liposyn II plus 50% glucose. Arterial blood was sampled daily. B and C: Glucose infusion elevated blood glucose (BG) levels consistently to moderate levels; coinfusion of lipid did not alter the degree of hyperglycemia (n = 26–34). D and E: Glucose infusion transiently elevated plasma insulin levels; coinfusion of lipid did not alter the degree of hyperinsulinemia (n = 13–15). F: Lipid infusion increased plasma FFA levels to a similar degree with and without coinfusion of glucose (n = 7–13). G: Oil Red O stain of liver showed end-organ lipid deposition in mice receiving intravenous Liposyn II. Data are mean ± SEM; P values by ANOVA. ns, nonsignificant. (A high-quality digital representation of this figure is available in the online issue.)