Table II.
Comparison of residues of the FcγRIIa–IgG1-Fc interaction with those of other human FcR and IgG subclasses
| Positiona | FcγRIIab | FcγRIII | FcγRI | FcεRI |
|---|---|---|---|---|
| Human FcRs | ||||
| 90 | W | W | W | W |
| 113 | W | W | W | W |
| 117 | P | A | I | D |
| 119 | V | H | V | V |
| 120 | K | K | N | K |
| 128 | K | K | K | F |
| 129 | S | G | A | A |
| 132 | F | Y | F | Y |
| 134 | H/R (R) | H | H | Y |
| 135 | L (S) | H | W | F |
| 160 | Y | S | K | Q |
| Eu Indexc | IgG1 | IgG2 | IgG3 | IgG4 |
| Human IgG subclasses | ||||
| 234 | L | V | L | F |
| 235 | L | A | L | L |
| 236 | G | – | G | G |
| 237 | G | G | G | G |
| 239 | S | S | S | S |
| 265 | D | D | D | D |
| 266 | V | V | V | V |
| 267 | S | S | S | S |
| 297 | N | N | N | N |
| 327 | A | G | A | G |
| 328 | L | L | L | L |
| 329 | P | P | P | P |
a
Position in amino acid sequence corresponding to the numbering scheme for crystal structures described in this article and reported previously (17, 24).
b
Residues in parentheses occur in FcγRIIb. The same numbering scheme has been used for FcγRIIb.
c
Numbering for IgG is the Eu Index (62).
–, deletion in the sequence.