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. 2012 Mar 1;122(3):1131. doi: 10.1172/JCI63366

Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

Fei Wang, Yasuo Okamoto, Isao Inoki, Kazuaki Yoshioka, Wa Du, Xun Qi, Noriko Takuwa, Koichi Gonda, Yasuhiko Yamamoto, Ryunosuke Ohkawa, Takumi Nishiuchi, Naotoshi Sugimoto, Yutaka Yatomi, Kunitoshi Mitsumori, Masahide Asano, Makoto Kinoshita, Yoh Takuwa
PMCID: PMC3287384  PMID: 22482119

Original citation: J. Clin. Invest. 2010;120(11):3979–3995. doi:10.1172/JCI42315.

Citation for this retraction: J. Clin. Invest. 2012;122(3):1131. doi:10.1172/JCI63366.

All authors agree to retract the above article due to multiple use of the same images or manipulation of data in Figures 1A, 2D, 5C, 6B, 6C, and 8A and Supplemental Figure 8E. They are also not able to provide some of the raw data that are used in Figures 2A, 2B, 5, 6, 7C, 8, and 9C, Supplemental Tables 1–4, and Supplemental Figures 2C, 3, 4, 5, 7C, 8AÐ8C, 8E, 8F, 10A, and 10B. The first author, Fei Wang, has admitted his sole responsibility in altering figures. The authors apologize and deeply regret the impact of this action. However, the authors stand behind data showing that genetic deletion of S1pr2 or pharmacological S1PR2 inhibition alleviates atherosclerosis in ApoeÐ/Ð mice fed a high-cholesterol diet.


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