Table 1.
Parameter | FVB-LF | FVB-HF | IGF-LF | IGF-HF |
---|---|---|---|---|
Body Weight (g) | 24.5 ± 0.6 | 31.7 ± 0.8* | 25.0 ± 0.9 | 30.6 ± 0.6*† |
Heart Weight (mg) | 122 ± 5 | 151 ± 6* | 136 ± 6* | 157 ± 4*† |
Tibial length (mm) | 18.1 ± 0.3 | 18.0 ± 0.2 | 18.0 ± 0.2 | 18.0 ± 0.2 |
Heart/Tibial Length (mg/mm) | 6.75 ± 0.27 | 8.38 ± 0.30* | 7.56 ± 0.33* | 8.75 ± 0.21*† |
Liver Weight (g) | 1.34 ± 0.05 | 1.58 ± 0.04* | 1.31 ± 0.03 | 1.59 ± 0.06*† |
Kidney Weight (g) | 0.31 ± 0.02 | 0.42 ± 0.02* | 0.33 ± 0.02 | 0.43 ± 0.02*† |
Plasma insulin (ng/ml) | 0.18 ± 0.02 | 4.07 ± 0.43* | 0.17 ± 0.03 | 4.46 ± 0.43*† |
HOMA-IR (mmol/l*µU/ml) | 0.93 ± 0.09 | 22.7 ± 2.6* | 1.06 ± 0.18 | 27.4 ± 3.6*† |
Triglycerides (mg/dl) | 45.5 ± 4.8 | 104.4 ± 7.0* | 47.9 ± 6.0 | 121.9 ± 14.6*† |
Plasma leptin (ng/ml) | 1.61 ± 0.23 | 7.14 ± 0.61* | 1.55 ± 0.21 | 7.23 ± 0.62*† |
Plasma IL-6 (pg/ml) | 69.9 ± 16.4 | 157.6 ± 25.5* | 77.8 ± 18.9 | 153.3 ± 15.4*† |
Plasma IGF-1 (ng/ml) | 100.3 ± 8.8 | 80.6 ± 5.8* | 140.2 ± 8.2* | 118.1 ± 12.2# |
Cardiac Tissue IGF-1 (ng/g) | 113.2 ± 16.9 | 88.0 ± 9.7* | 149.5 ± 15.4* | 133.8 ± 18.0 |
Diastolic blood pressure (mmHg) | 78.3 ± 4.9 | 81.0 ± 3.7 | 81.9 ± 4.4 | 79.6 ± 4.6 |
Systolic blood pressure (mmHg) | 108.6 ± 6.5 | 113.9 ± 3.8 | 111.1 ± 3.3 | 113.1 ± 4.2 |
Heart Rate (bpm) | 431 ± 15 | 432 ± 17 | 447 ± 23 | 445 ± 16 |
Wall Thickness (mm) | 0.79 ± 0.04 | 0.90 ± 0.04* | 0.88 ± 0.04 | 0.89 ± 0.03* |
EDD (mm) | 2.64 ± 0.10 | 2.91 ± 0.15* | 2.77 ± 0.08 | 2.98 ± 0.08*† |
ESD (mm) | 1.36 ± 0.11 | 1.83 ± 0.15* | 1.22 ± 0.10 | 1.55 ± 0.04*#† |
LV Mass (mg) | 60.2 ± 5.7 | 86.7 ± 11.3* | 75.0 ± 3.5* | 85.3 ± 4.6* |
Normalized LV Mass (mg/g) | 2.52 ± 0.23 | 2.76 ± 0.41 | 3.08 ± 0.22* | 2.90 ± 0.17* |
Fraction Shortening (%) | 48.8 ± 2.9 | 38.3 ± 1.9* | 45.5 ± 3.7 | 47.8 ± 1.1# |
LF = low fat; HF = high fat; EDD = end diastolic diameter; ESD = end systolic diameter; LV = left ventricular. Mean ± SEM, n = 13 mice (8 mice for echocardiography) per group,
p < 0.05 vs. FVB-LF group,
p < 0.05 vs. FVB-LF group,
p < 0.05 vs. FVB-HF group.