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. Author manuscript; available in PMC: 2013 Feb 28.
Published in final edited form as: Biochemistry. 2012 Feb 10;51(8):1730–1739. doi: 10.1021/bi201159b

Figure 2.

Figure 2

Enhancement of topoisomerase II-mediated DNA cleavage by m-AMSA and derivatives. The effects of m-AMSA (closed circles), AMSA (open circles), and o-AMSA (squares) (panels A and B), 1’-OH 3’-OCH3 (closed circles), 1’-OH (open circles) and 1’-OH 2’-OCH3 (squares) (panels C and D), and 3’-OCH3 (closed circles), N-phenyl (open circles), and 2’-OCH3 (squares) (panels E and F) on the cleavage of negatively supercoiled plasmid DNA by human topoisomerase IIα (panels A, C, and E) and topoisomerase IIβ (panels B, D, and F) were determined. Error bars represent the standard deviation of three independent experiments. Data for m-AMSA are included as dashed lines in panels C–F for comparison.