Table 1.

Summary of vaginal cytokines and chemokines evaluated during vaginal candidiasis

	Cytokine	Reported outcome in VVC/RVVC			References
		Humans	Mice	Rats
Th1	IL-2	P−	P+	P+	[37, 43, 44, 52, 114]
	IL-12	P−	P−	P+	[34, 37, 52, 114]
	IFN-γ	P−, S+	P−	P+	[34, 37, 51, 52]
Th2	IL-4	P−, S+	S+	P−	[34, 37, 42, 43, 51, 115]
	IL-5	P−		P−	[37, 115]
	IL-13	S+			[115]
Th17	IL-23	P−	P−		[14, 58](Fidel, submitted)
	IL-17	P+/−	P+/−		[13, 58](Fidel, submitted)
	IL-22		P−		(Fidel, submitted)
Proinflammatory	IL-1α	P−			[34]
	IL-6	P−		P+	[13, 34, 44, 114]
	G-CSF	P−	P−		[13](Fidel, unpublished data)
	TNF-α	P−		P+	[34, 114]
Regulatory	TGF-β	I+	I+		[29, 34, 35, 43]
	IL-10	P−	P−, S+	P+	[29, 34, 43, 44, 114]
Chemokines	MCP-1		P−		[29, 30]
	RANTES		P−		[30]
	IL-8/MIP-2	P−, S+	P−		[30, 51, 71]
	MIP-1α		P−		[30]

P, protection; S, susceptibility; I, immunoregulation; +, reported role; −, reported lack of a role