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. Author manuscript; available in PMC: 2012 Aug 23.
Published in final edited form as: Nature. 2012 Feb 22;482(7386):495–500. doi: 10.1038/nature10822

Figure 2. Klhl12 is a substrate adaptor for Cul3 in mESCs.

Figure 2

a. D3 mESCs were subjected to differentiation, and mRNA-levels of indicated proteins were measured by qRT-PCR. b. Klhl12 protein is downregulated upon differentiation, as observed by immunoblot of above samples. c. Klhl12 is a critical Cul3-adaptor in mESCs. D3 mESCs were sensitized towards altered integrin-signaling with dasatinib and monitored for compaction by phase (upper panel) or confocal microscopy (actin, red; vinculin, green; DNA, blue).