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. 2011 Apr 23;60(5):1424–1434. doi: 10.2337/db10-1106

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 1. — Altered body composition but normal glucose tolerance in caloric-restricted (CR) ob/ob mice. Average daily food intake (A), body weight (B), body composition (C), and adipose tissue weight (D) of ob/ob mice are shown. E: GTT performed on mice during 3rd week of treatment after 6 h of fasting. F: Serum insulin levels collected before and 30 min after glucose injection. Numbers of animals are shown in each figure. RF, random fed. ^aP < 0.05 vs. wt RF saline; ^bP < 0.05 vs. ob/ob RF saline; ^cP < 0.05 vs. ob/ob CR saline; *P < 0.05 vs. basal conditions of same treatment group. DEXA, dual-energy X-ray absorptiometry; RF, random fed; wt, wild type.