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. Author manuscript; available in PMC: 2013 Feb 21.
Published in final edited form as: Biochemistry. 2012 Feb 9;51(7):1486–1499. doi: 10.1021/bi201794x

Figure 6.

Figure 6

“S destabilization effect” for the lesion-containing DNA duplexes. The structures are the same as Figure 2 except rotated to highlight the steric hinderance. Steric hindrance between the adduct benzylic rings and the neighboring DNA atoms is associated only with the 3′-side intercalation of the S adducts, while no such crowding is present in the case of the 5′-intercalated R stereoisomeric adducts. The color code is the same as in Figure 2. For the S-B[c]Ph-N6-dA adduct, the steric hinderance is essentially absent.