Table 7.
Adjusted mean of FVIII activity (%) by VWF SNPs
| VWF SNP | ABO adjusted | FVIII activity for VWF genotype, mean (SEM) |
P | ||
|---|---|---|---|---|---|
| AA | AB | BB | |||
| EA women, N = 4282*†§ | |||||
| RS216315 | No | 126.50 (0.54) | 120.66 (1.22) | 117.91 (5.02) | 2.4 × 10−5 |
| Yes | 126.53 (0.51) | 120.53 (1.14) | 117.88 (4.69) | 2.7 × 10−6 | |
| RS216318 | No | 126.51 (0.54) | 120.66 (1.22) | 117.87 (4.90) | 2.2 × 10−5 |
| Yes | 126.54 (0.51) | 120.51 (1.14) | 117.89 (4.58) | 2.3 × 10−6 | |
| RS216299 | No | 126.30 (0.55) | 121.67 (1.20) | 121.81 (4.46) | 1.5 × 10−3 |
| Yes | 126.42 (0.51) | 121.19 (1.12) | 120.51 (4.17) | 6.2 × 10−5 | |
| RS216295 | No | 126.34 (0.55) | 121.70 (1.21) | 119.86 (4.92) | 1.1 × 10−3 |
| Yes | 126.42 (0.51) | 121.36 (1.13) | 118.76 (4.59) | 8 × 10−5 | |
| RS216298 | No | 126.32 (0.54) | 121.61 (1.21) | 119.77 (4.80) | 8.7 × 10−4 |
| Yes | 126.43 (0.51) | 121.15 (1.13) | 118.81 (4.48) | 3.6 × 10−5 | |
| EA men, N = 3774*† | |||||
| RS1063857 | No | 118.24 (0.83) | 122.25 (0.77) | 125.11 (1.45) | 1.9 × 10−5 |
| Yes | 118.50 (0.78) | 122.11 (0.73) | 124.81 (1.38) | 4.3 × 10−5 | |
| RS723190‡§ | No | 120.42 (0.56) | 125.67 (1.57) | 1.6 × 10−3 | |
| Yes | 120.36 (0.53) | 126.13 (1.48) | 2.5 × 10−4 | ||
SNP indicates single nucleotide polymorphism; and EA, Americans of European descent.
*
All means were adjusted for age, sex, BMI, diabetes, hypertension, and ever-smoking status.
†
RS7968035, RS2239143, RS16932374, and RS3213721 were too sparse to analyze for both EA women and men.
‡
Due to small counts, AB genotype was combined with the minor BB genotype.
§
All SNPs except RS723190 were previously associated with VWF Ag.31