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. 1988 Feb;81(2):611–614. doi: 10.1172/JCI113361

Relation of mesangial IgA glomerulonephritis to polymorphism of immunoglobulin heavy chain switch region.

A G Demaine 1, M Rambausek 1, J F Knight 1, D G Williams 1, K I Welsh 1, E Ritz 1
PMCID: PMC329611  PMID: 2892861

Abstract

We have investigated the switch regions of Ig heavy chain genes of patients with IgA glomerulonephritis (IgA-GN) using restriction fragment length polymorphism (RFLP) analysis. Genomic DNA from patients and controls was digested with the restriction endonuclease Sst I and transferred to nylon membranes using the Southern blot procedure and hybridized with a probe homologous to the switch region of the Ig C mu gene (S mu) which detects RFLPs in both S mu and the switch region of the Ig C alpha 1 gene (S alpha 1). A significant decrease in the frequency of the 2.6;2.1 kb heterozygous S mu phenotype was found in patients with IgA-GN (P = 0.003). With respect to the S alpha 1 region, there was a significant increase in the frequency of the 7.4 kb S alpha 1 phenotype (P = 0.002). In addition, a significant increase in the frequency of the 7.4 kb S alpha 1 allele was found (P = 0.0002). These results suggest that gene(s) within the Ig heavy chain loci may be important in the pathogenesis of IgA-GN.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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