Table 2 . Sets of values for the major parameters resulting in low, middle, and high rates of adaptive evolution.
Parameter | Low | Middle | High |
---|---|---|---|
No. of simultaneously targeted loci, L* | 1 | 3 | 5 |
Mutation rate (/bp/generation), μ | 7.3 × 10−7 | 6.0 × 10−6 | 4.9 × 10−5 |
Set point viral load (infected cells), N* | 1 × 107 | 5 × 107 | 1 × 108 |
Viral generation length (days), g | 2 | 1.5 | 1 |
Day of seroconversion (days p.i.), t* | 28 | 25 | 21 |
Cell killing rate (day−1), c | 0.15 | 0.30 | 0.45 |