Figure 8.

Acute and long-term effects of repeated administrations of methylone (MDMC) in single-housed male rats. MDMC-treated rats received s.c. injections of 3.0 or 10.0 mg/kg at 0, 2, and 4 h (denoted by arrows in panel a). Control rats received s.c. saline injections (1 mL/kg) on the same schedule. Core temperature and motor behavior were assessed every hour beginning at time zero, whereas post-mortem brain tissue amines were assessed 2 weeks after binge dosing. Data are mean±SEM for N=6–7 rats per group, expressed as core temperature in °C (panel a) and summed behavioral scores for ambulation (Amb), rearing (Rear), and forepaw treading (Tread) (panel b). Tissue amine concentrations in cortex (panel c) and striatum (panel d) are expressed as percentage of values for saline-treated rats (% control). Control amine levels in cortex were 273±12, 29±3, and 284±23 pg/mg for norepinephrine (NE), dopamine (DA), and serotonin (5-HT), respectively. Control amine levels in striatum were 605±45, 11511±708, and 206±18 pg/mg for NE, DA and 5-HT, respectively. In panel (a), filled symbols indicate significant differences with respect to saline-treated control at a given time point, p<0.05. In panels (b–d), ^*p<0.05 compared with saline control group (Newman–Keul's post hoc test).