TABLE 1.

The temperature response after icv injection of galanin-like peptide (GALP) in IL-1α/β, IL-1β or IL-1RI −/− mice

A) The change in temperature at 30 min

	Δ °C at 30 min
	Vehicle	GALP
Wild-type	1.0 ± 0.5	−1.4 ± 0.7 a
IL-1α/β −/−	1.1 ± 0.1	−1.2 ± 0.8 a
Wild-type	0.1 ± 0.1	−2.1 ± 0.4 a
IL-1β −/−	0.4 ± 0.2	−1.9 ± 0.8 a
Wild-type	1.3 ± 0.4	−2.9 ± 0.4 b
IL-1R1 −/−	0.7 ± 0.3	−3.2 ± 0.2 b

The change (Δ) in temperature was measured at 30 min after icv injection of 1.5 nmol GALP or vehicle (1 μl saline)

Data are mean ± SEM for n = 5 per group.

^aP < 0.05

^bP < 0.001 vs respective vehicle