B) The integrated temperature response (AUC, °C h) for 2-10 h

	AUC (°C h)
	Vehicle	GALP
Wild Type	10.7 ± 2.4	19.7 ± 1.9a
IL-1α/β −/−	8.2 ± 1.7	12.8 ± 1.9
Wild Type	16.1 ± 1.1	29.1 ± 1.6b
IL-1β −/−	21.0 ± 1.6	21.1 ± 4.1
Wild Type	17.7 ± 1.7	24.8 ± 1.6c
IL-1R −/−	13.3 ± 1.3	16.3 ± 1.5

The AUC for the temperature response was measured between 2-10 h after icv injection of 1.5 nmol GALP or vehicle (1 μl saline)

Data are mean ± SEM for n = 5 per group.

^aP < 0.05

^bP < 0.01

^cP < 0.001 vs respective vehicle