Abstract
This paper presents a new method for representing DNA sequences. It permits the representation and investigation of patterns in sequences, visually revealing previously unknown structures. Based on a technique from chaotic dynamics, the method produces a picture of a gene sequence which displays both local and global patterns. The pictures have a complex structure which varies depending on the sequence. The method is termed Chaos Game Representation (CGR). CGR raises a new set of questions about the structure of DNA sequences, and is a new tool for investigating gene structure.
Full text
PDF







Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Fichant G., Gautier C. Statistical method for predicting protein coding regions in nucleic acid sequences. Comput Appl Biosci. 1987 Nov;3(4):287–295. doi: 10.1093/bioinformatics/3.4.287. [DOI] [PubMed] [Google Scholar]
- Senapathy P. Origin of eukaryotic introns: a hypothesis, based on codon distribution statistics in genes, and its implications. Proc Natl Acad Sci U S A. 1986 Apr;83(7):2133–2137. doi: 10.1073/pnas.83.7.2133. [DOI] [PMC free article] [PubMed] [Google Scholar]