Figure 2.

(A) Model of the GABA_C receptor binding site showing GABA docked into the binding pocket. For ease of viewing, only two of the five subunits are shown. Inset: Enlargement of the binding pocket showing GABA surrounded by aromatic binding site residues. (B) The location of GABA docked into the GABA_C receptor binding pocket is consistent with a cation-π interaction at Y198 as previously shown.¹¹ The model reveals there is also the potential for aromatic stabilization of GABA by Tyr102 and Phe138, as suggested by the data. The location of Arg104, which has previously been shown to be critical for GABA binding, is also consistent with the presence of a hydrogen bond with Tyr247 as suggested by the data.