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. Author manuscript; available in PMC: 2012 Mar 23.
Published in final edited form as: Neuropharmacology. 2009 Nov 24;58(3):650–659. doi: 10.1016/j.neuropharm.2009.11.008

Figure 2.

Figure 2

Activation of SK channels with systemic CyPPA depresses locomotor responding in C57BL/6NHsd mice. (A) Effect of CyPPA (15 mg/kg) on mean distance traveled during the 60 min period in the open field. Student’s t-test analysis determined locomotor depression of CyPPA to return to that of 5% Cremophor vehicle levels by 35 min. (B) Effect of CyPPA on immobility over the 60 min period. Students t-test determined that measures of mobility returned to vehicle levels by 35 min. Shaded region depicts the 30 min post-injection interval over which CyPPA impaired locomotor behavior in mice. In light of this effect, a 30-min delay was imposed after CyPPA administration and before behavioral testing for all subsequent experiments. Error bars are SEM. *, P < 0.05 vs. vehicle. Vehicle, n = 8; 15 mg/kg CyPPA, n = 8.