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. 1990 Aug 11;18(15):4361–4368. doi: 10.1093/nar/18.15.4361

Molecular mechanisms underlying the expression of the human HOX-5.1 gene.

L Cianetti 1, A Di Cristofaro 1, V Zappavigna 1, L Bottero 1, G Boccoli 1, U Testa 1, G Russo 1, E Boncinelli 1, C Peschle 1
PMCID: PMC331252  PMID: 1975093

Abstract

The complex mechanisms underlying homeobox genes expression involve regulation at transcriptional, post-transcriptional and translational levels. The multiple transcripts of the human HOX-5.1 gene are expressed differentially in tissue- and stage-specific patterns during embryogenesis, and differentially induced by retinoic acid (RA) in human embryonal carcinoma (EC) NT2/D1 cells. We have sequenced 6.3 Kb of the genomic region containing the HOX-5.1 gene and analyzed its mechanisms of expression. Two alternative promoters underlie the transcription of two classes of HOX-5.1-specific mRNAs. These classes differ in tissue and subcellular distribution, induction by RA, structure of the 5'-UT region and mRNA stability: these features are compatible with a differential function of the two classes of transcripts in embryogenesis.

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