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(A) Crystal structure of RF3-GDPNP (green) on the ribosome (30S subunit in pale yellow and 50S subunit in pale blue). EFG (blue) aligned by G domain to the RF3 position in Zhou et al. (2011) allows domain IV of EFG to avoid steric clashes with the A site tRNA (orange). (B) EFG as seen in crystal structures with GDP and fusidic acid (red) (Gao et al. 2009) shows many steric clashes with A site tRNA as opposed to the EFG as aligned with RF3 G domain (again in blue).
