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. 1989 Jan 11;17(1):11–18. doi: 10.1093/nar/17.1.11

Isolation of the Xenopus homolog of int-1/wingless and expression during neurula stages of early development.

J Noordermeer 1, F Meijlink 1, P Verrijzer 1, F Rijsewijk 1, O Destrée 1
PMCID: PMC331531  PMID: 2911462

Abstract

We have isolated the Xenopus homolog (Xint-1) of the mouse protooncogene int-1 from a neurula stage 17 cDNA library. The deduced protein sequence of Xint-1 includes 371 amino acids. The Xint-1 protein is more similar to the mammalian int-1 product (69%), than to the Drosophila counterpart of int-1, wingless (50%). Xint-1 shares several characteristics of secreted proteins with the other int-1 homologs: it has a hydrophobic leader, multiple conserved potential N-linked glycosylation sites and is rich in cysteine residues. All 23 cysteines are conserved in the three proteins. Xint-1 is transiently expressed during the neurula stages of early Xenopus development.

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Selected References

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