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Preleukemic cooperation of Rara haploinsufficiency and PML-RARA. Immunophenotype of bone marrow cells from the indicated littermate-matched mice at 8 weeks. (A-B) Myeloid immunophenotype by Gr1, CD115, cKit, and CD34. (C-D) Progenitor immunophenotype by lineage (CD3, CD8, CD4, CD19, B220, Gr1, and Terr-119), cKit, Sca, CD34, and FcγRIII-R. (E) Peripheral blood immunophenotype by CD3 and Gr1. (F) Neutrophil counts assessed by Coulter counter at 4 and 6 months of age.
