Nutlin-3a induces expression of cell cycle arrest genes and mediators of apoptosis in human and mouse cancer OSE cells that express wild-type TRP53 and Trp53, respectively. A, OSE cells from mouse and human serous adenocarcinoma express elevated levels of wild-type Trp53/TP53 as shown by RT-PCR. B, Nutlin-3a induces the expression of cell cycle control genes, DNA stability genes, and mediators of apoptosis in human and mouse serous adenocarcinoma OSE cells that express wild-type P53. C, Trp53/P53 is expressed at low levels and is not induced by nutin-3a in mouse Trp53− cells and human TP53− SKOV-3 cells.