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. 2010 Nov 30;117(4):1408–1414. doi: 10.1182/blood-2010-07-299099

Figure 3.

Figure 3

Dimerized β2GPI increases thrombus size, carotid artery, and peritoneal macrophages TF activity in mice through an interaction with ApoER2. ApoER2+/+ (filled bars) or ApoER2−/− (open bars) mice were injected with dimeric β2GPI or monomer β2GPI as control. (A) Thrombi were induced in the animals, and thrombus size was measured in square microns (μm2). The data are expressed as mean ± SD (5-10 animals were used per group). (B) In peritoneal macrophages as described in “Statistical analysis,” TF activity was determined with a commercial chromogenic assay for Xa formation. Results are expressed as means ± SEM in pM · mg−1 · mL−1. Experiments were assayed in duplicate and repeat thrice. ¶Statistically different from apoER2+/+ treated with control; (A, P = .011 and B, P = .023). *Statistically different from apoER2+/+ treated with dimer (A, P = .007 and B, P = .013). **Statistically different from apoER2−/− treated with dimmer (A, P < .0001 and B, P < .0001).