Table 7.
Comparison of lumefantrine concentrations in clinical samples using the HPLC-UV method (conc. 1) versus LC–MS/MS method (conc. 2).
| Sample # | Conc. 1 | Conc. 2 | %dev |
|---|---|---|---|
| S1 | 9303 | 10,900 | 15.8 |
| S2 | 9192 | 10,700 | 15.2 |
| S3 | 10,623 | 11,500 | 7.93 |
| S4 | 10,539 | 11,600 | 9.59 |
| S5 | 11,820 | 12,800 | 7.96 |
| S6 | 13,151 | 15,400 | 15.8 |
| S7 | 11,217 | 11,500 | 2.49 |
| S8 | 8236 | 8400 | 1.97 |
| S9 | 3826 | 4440 | 14.9 |
| S10 | 2289 | 1980 | −14.5 |
| S11 | 1356 | 1380 | 1.79 |
| S12 | 940 | 1000 | 6.17 |
| S13 | 699 | 735 | 5.09 |
| S14 | 437 | 451 | 3.15 |
| S15 | 352 | 351 | −0.28 |
| S16 | 310 | 308 | −0.65 |
| S17 | 5339 | 5800 | 8.28 |
| S18 | 4762 | 4860 | 2.04 |
| S19 | 5055 | 5410 | 6.79 |
| S20 | 5374 | 5820 | 7.97 |
| S21 | 4952 | 5340 | 7.54 |
| S22 | 5777 | 6280 | 8.34 |
| S23 | 4641 | 4750 | 2.33 |
| S24 | 3047 | 3210 | 5.22 |
| S25 | 1356 | 1230 | −9.74 |
| S26 | 632 | 613 | −2.99 |
| S27 | 311 | 272 | −13.3 |
| S28 | 247 | 254 | 2.98 |
| S29 | 184 | 203 | 9.78 |
| S30 | 119 | 111 | −6.74 |
| S31 | 100 | 89.4 | −11.1 |
| S32 | 103 | 99.4 | −3.31 |
| S33 | 13,893 | 14,900 | 7.00 |
| S34 | 13,306 | 15,700 | 16.5 |
| S35 | 13,359 | 14,700 | 9.56 |
| S36 | 12,457 | 13,800 | 10.2 |
| S37 | 14,193 | 15,800 | 10.7 |
| S38 | 18,966 | 21,300 | 11.6 |
| S39 | 16,825 | 18,300 | 8.40 |
| S40 | 11,167 | 12,900 | 14.4 |
| S41 | 8082 | 8660 | 6.91 |
| S42 | 4734 | 4910 | 3.64 |
| S43 | 2728 | 2820 | 3.30 |
| S44 | 1766 | 1900 | 7.34 |
| S45 | 1272 | 1420 | 11.0 |
| S46 | 808 | 841 | 3.98 |
| S47 | 623 | 665 | 6.52 |
| S48 | 524 | 540 | 3.00 |
| S49 | 17,221 | 18,900 | 9.29 |
| S50 | 16,701 | 16,400 | −1.82 |
| S51 | 16,471 | 17,000 | 3.16 |
| S52 | 15,334 | 15,900 | 3.63 |
| S53 | 14,836 | 15,200 | 2.42 |
| S54 | 14,949 | 15,200 | 1.66 |
| S55 | 12,217 | 15,100 | 21.1 |
| S56 | 9168 | 10,900 | 17.3 |
| S57 | 4512 | 4720 | 4.50 |
| S58 | 1810 | 1920 | 5.92 |
| S59 | 984 | 1060 | 7.43 |
| S60 | 700 | 762 | 8.52 |
| S61 | 498 | 539 | 7.91 |
| S62 | 328 | 336 | 2.41 |
| S63 | 272 | 288 | 5.86 |
| S64 | 223 | 219 | −1.91 |
| S65 | 9508 | 9490 | −0.19 |
| S66 | 9680 | 8430 | −13.8 |
| S67 | 9061 | 9200 | 1.53 |
| S68 | 8903 | 8800 | −1.16 |
| S69 | 8652 | 8550 | −1.19 |
| S70 | 15,601 | 14,900 | −4.60 |
| S71 | 14,278 | 14,400 | 0.85 |
| S72 | 10,467 | 10,600 | 1.26 |
| S73 | 4348 | 4380 | 0.74 |
| S74 | 2612 | 2550 | −2.40 |
| S75 | 1508 | 1640 | 8.39 |
| S76 | 1167 | 1230 | 5.22 |
| S77 | 910 | 951 | 4.44 |
| S78 | 516 | 535 | 3.65 |
| S79 | 491 | 476 | −3.10 |
| S80 | 270 | 268 | −0.91 |
| S81 | 10,022 | 10,600 | 5.61 |
| S82 | 9792 | 9760 | −0.33 |
| S83 | 9293 | 9850 | 5.82 |
| S84 | 8641 | 9200 | 6.27 |
| S85 | 8002 | 9120 | 13.1 |
| S86 | 19,647 | 16,900 | −15.0 |
| S87 | 15101 | 13,800 | −9.00 |
| S88 | 9589 | 8960 | −6.78 |
| S89 | 2484 | 2460 | −0.98 |
| S90 | 1250 | 1230 | −1.64 |
| S91 | 728 | 719 | −1.18 |
| S92 | 430 | 434 | 0.93 |
| S93 | 332 | 315 | −5.15 |
| S94 | 279 | 265 | −5.05 |
| S95 | 196 | 185 | −5.77 |
| S96 | 191 | 184 | −3.73 |
%dev: % deviation.