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ONX 0912 triggers antitumor activity in MM patient cells. (A) Purified patient MM cells (CD138-positive) were treated with ONX 0912 (10nM), and cell death was measured using trypan blue exclusion assay. Data presented are mean ± SD of triplicate samples (P < .05 for all patient samples). (B) PBMCs from healthy donors were treated with indicated concentrations of ONX 0912 and then analyzed for viability using MTT assay. Data presented are mean ± SD (n = 3; P < .05).
