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. 1990 Oct 11;18(19):5673–5676. doi: 10.1093/nar/18.19.5673

Rat DNA polymerase beta gene can join in excision repair of Escherichia coli.

T Ohnishi 1, S Yuba 1, T Date 1, H Utsumi 1, A Matsukage 1
PMCID: PMC332299  PMID: 2216761

Abstract

Though DNA polymerase I (poll) of Escherichia (E.) coli is understood to play a role in repair synthesis of excision repair, it is still obscure whether DNA polymerase beta (pol beta) plays a similar role in eukaryotic cells. To estimate the role of pol beta in excision repair processes, we inserted the rat pol beta gene into several mutant E. coli defective in a diverse set of enzymatic activities of poll. UV resistance was seen only when the 5'----3' exonuclease (exo) activity of poll molecules remained. Therefore it is suggested that 5'----3' exo activity as well as pol beta activity are essential for repair synthesis of excision repair in eukaryotic cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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