Table 2.
Chromosomal Regions with Most Frequent Gains (Minimal Overlapping Regions) Coding for Known Genes Observed in at Least 3/15 Cortisol-Secreting ACAs (Frequency, ≥20%) According to CNAs Detected by SNP Arrays.
| Cytoband | Altered Samples | No. Genes | Selected Genes |
| Already reported regions* | |||
| 5p15.33 | 207A, 271A, 802A | 28 | NKD2, PDCD6 |
| 9q34.2-34.3 | 207A, 271A, 802A | 100 | COBRA1, EDF1, FBXW5, LHX3, NOTCH1, RXRA, SNAPC4, TRAF2 |
| 12q12 | 1 | ||
| 16q24.3- | 207A, 271A, 802A | 14 | FANCA, MC1R, PRDM7 |
| 20p11.1-q11.21 | 170A, 283A, 802A | 3 | |
| Newly observed regions | |||
| 6q16.1 | 283A, 474A, 802A | 1 | EPHA7 |
| 7p22.3-22.2 | 207A, 271A, 802A | 34 | CYP2W1, MAFK, NUDT1, PDGFA, PRKAR1B, UNCX |
| 8q24.3 | 207A, 271A, 802A | 102 | ARC, BAI1, SLURP1, ADCK5, CYP11B2, FOXH1, HSF1, LRRC14, MAFA, MAPK15, MFSD3, PUF60, RECQL4 |
| 11p15.5 | 207A, 271A, 802A | 74 | CD151, CTSD, H19, HRAS, IFITM1, IGF2, INS, INS-IGF2, IRF7, LRDD, PHRF1, RPLP2, SCT |
| 11q11 | 283A, 350A, 802A | 3 | |
| Xq28 | 207A, 271A, 802A | 81 | DKC1, IRAK1, L1CAM, MECP2 |
Selected genes: genes considered relevant for tumorigenesis or glucocorticoid production/effects. They include potential oncogenes and tumor suppressor genes, growth or transcription factors, cell differentiation markers, protein kinases (according to the gene set enrichment analysis, see also Table W4), genes involved in steroidogenesis (underlined), or glucocorticoid regulation or in Wnt/β-catenin signaling.
Localization, length, and CN score of the CNAs are reported in Table W3.
Regions already reported in previous studies with conventional comparative genomic hybridization [3,12,13].