Figure 1. Pedigree charts of families found to carry disease-causing APP mutations and locus duplications.

Information for each individual is (from top to bottom): age at onset (in affected individuals) or age at last examination (unaffected individuals); APOE genotype; and APP mutation finding. Probands are indicated by arrows. No DNA or clinical information was available from the founders (?). dup = carriers of APP duplication; mut = carriers of Val717Leu mutation.