Table II.
Association of genetic loci from previous GWAS with breast cancer risk in women of African ancestry
| Locus (gene) | SNP | Allelesa (ref/risk) | Risk allele frequency |
Per-allele OR (95% CI)b | P for trend | Heterozygous OR (95% CI)b | Homozygous OR (95% CI)b | ||
| Case | Control | Two-sided | One-sided | ||||||
| 1p11.2 | rs11249433 | T/C | 0.102 | 0.101 | 1.07 (0.89–1.28) | 0.46 | 0.23 | 1.03 (0.84–1.26) | 1.41 (0.74–2.68) |
| 2q35 | rs13387042 | G/A | 0.768 | 0.749 | 0.99 (0.87–1.12) | 0.82 | 0.59 | 0.97 (0.69–1.36) | 0.96 (0.68–1.34) |
| 3p24 (SLC4A7) | rs4973768 | C/T | 0.355 | 0.350 | 1.06 (0.94–1.18) | 0.35 | 0.17 | 0.97 (0.82–1.14) | 1.20 (0.94–1.54) |
| 5p12 | rs10941679 | A/G | 0.178 | 0.189 | 0.94 (0.81–1.08) | 0.35 | 0.82 | 0.88 (0.74–1.04) | 1.07 (0.70–1.65) |
| rs4415084 | C/T | 0.649 | 0.655 | 0.95 (0.85–1.07) | 0.42 | 0.79 | 0.85 (0.66–1.09) | 0.87 (0.67–1.12) | |
| 5q11.2 (MAP3K1) | rs889312 | A/C | 0.321 | 0.340 | 0.93 (0.83–1.05) | 0.24 | 0.88 | 0.97 (0.82–1.14) | 0.84 (0.65–1.09) |
| 6q22 (RNF146) | rs2180341 | A/G | 0.341 | 0.316 | 1.09 (0.97–1.22) | 0.16 | 0.078 | 1.14 (0.97–1.35) | 1.12 (0.86–1.45) |
| 6q25.1 (ESR1/C6orf97) | rs2046210 | C/T | 0.646 | 0.627 | 1.02 (0.91–1.14) | 0.74 | 0.37 | 0.95 (0.75–1.21) | 1.01 (0.79–1.29) |
| rs9397435 | A/G | 0.093 | 0.074 | 1.34 (1.10–1.63) | 0.0035 | 0.0018 | 1.33 (1.07–1.65) | 1.83 (0.78–4.28) | |
| 8q24.21 | rs13281615 | A/G | 0.435 | 0.440 | 1.00 (0.89–1.11) | 0.95 | 0.52 | 1.08 (0.90–1.28) | 0.97 (0.78–1.21) |
| 9p21.3 (CDKN2BAS) | rs1011970 | G/T | 0.337 | 0.342 | 0.90 (0.80–1.01) | 0.076 | 0.96 | 0.90 (0.76–1.06) | 0.83 (0.64–1.06) |
| 10p15.1 | rs2380205 | T/C | 0.406 | 0.416 | 0.97 (0.86–1.09) | 0.60 | 0.70 | 1.00 (0.84–1.19) | 0.91 (0.73–1.15) |
| 10q21.2 (ZNF365) | rs10995190 | A/G | 0.808 | 0.832 | 0.88 (0.77–1.02) | 0.089 | 0.96 | 0.77 (0.48–1.23) | 0.70 (0.44–1.11) |
| 10q22.3 (ZMIZ1) | rs704010 | G/A | 0.061 | 0.076 | 1.04 (0.84–1.29) | 0.71 | 0.35 | 1.01 (0.80–1.28) | 1.39 (0.56–3.42) |
| 10q26 (FGFR2) | rs1219648 | A/G | 0.443 | 0.431 | 1.06 (0.95–1.19) | 0.26 | 0.13 | 1.06 (0.89–1.26) | 1.14 (0.91–1.42) |
| rs2981582 | C/T | 0.491 | 0.480 | 1.03 (0.92–1.15) | 0.59 | 0.29 | 0.99 (0.83–1.19) | 1.06 (0.86–1.32) | |
| rs2981578 | A/G | 0.905 | 0.871 | 1.24 (1.04–1.47) | 0.018 | 0.009 | 1.79 (0.95–3.37) | 2.08 (1.12–3.86) | |
| 11p15 (LSP1) | rs3817198 | T/C | 0.129 | 0.159 | 0.85 (0.73–0.99) | 0.040 | 0.98 | 0.84 (0.70–1.00) | 0.77 (0.44–1.34) |
| 11q13.2 | rs614367 | C/T | 0.139 | 0.128 | 1.09 (0.93–1.28) | 0.29 | 0.14 | 1.09 (0.91–1.31) | 1.21 (0.64–2.29) |
| 14q24.1 (RAD51B) | rs999737 | T/C | 0.974 | 0.967 | 0.93 (0.67–1.27) | 0.64 | 0.68 | 1.21 (0.16–8.96) | 1.11 (0.15–8.04) |
| 16q12 (TOX3) | rs3803662 | C/T | 0.510 | 0.516 | 0.96 (0.86–1.07) | 0.41 | 0.79 | 0.80 (0.66–0.97) | 0.91 (0.73–1.13) |
| rs3104793 | T/C | 0.625 | 0.585 | 1.12 (1.00–1.25) | 0.045 | 0.022 | 1.07 (0.86–1.33) | 1.23 (0.98–1.55) | |
| 17q23.2 (STXBP4) | rs6504950 | A/G | 0.635 | 0.654 | 0.90 (0.80–1.01) | 0.068 | 0.97 | 0.84 (0.66–1.07) | 0.79 (0.61–1.01) |
| 19p13 | rs2363956 | G/T | 0.515 | 0.501 | 1.08 (0.97–1.20) | 0.18 | 0.09 | 1.11 (0.92–1.35) | 1.16 (0.94–1.44) |
| rs8170 | C/T | 0.196 | 0.185 | 1.08 (0.94–1.24) | 0.27 | 0.13 | 1.05 (0.89–1.24) | 1.35 (0.86–2.14) | |
Bold represents ORs and P values of three SNP that were statistically significant and in the same direction as those reported in previous studies.
a
Reference/risk alleles in previous GWAS on the forward strand.
b
OR (95% CI) from logistic regressions adjusted for study site and African ancestry.