Table 1.
Edema after ICH
| A. Wild-type, CCL2−/−, and CCR2−/− mice were subjected to ICH and water content was calculated, as described in Materials and Methods. Data are mean±SD (n=6). | ||||
|---|---|---|---|---|
| Genotype (time post ICH) | Water content (%) | |||
| Contralateral | Ipsilateral | Cerebellum | ||
| Wt | Day 1 | 76.67±0.24 | 79.67±0.82 | 74.48±0.71 |
| Day 3 | 76.92±0.57 | 78.9±0.62 | 74.94±0.75 | |
| Day 7 | 76.43±0.85 | 77.04±0.92* | 74.39±1.97 | |
| CCL2−/− | Day 1 | 76.55±0.64 | 77.87±0.50# | 74.73±0.66 |
| Day 3 | 76.53±0.29 | 78.52±0.36 | 74.89±0.30 | |
| Day 7 | 76.81±0.64 | 78.90±0.30*,# | 74.95±0.36 | |
| CCR2−/− | Day 1 | 76.80±0.32 | 78.11±0.28# | 74.58±0.30 |
| Day 3 | 76.81±0.48 | 78.63±0.60 | 74.91±0.50 | |
| Day 7 | 76.56±0.45 | 79.73±0.84*,# | 74.83±0.63 | |
| B. CCL2−/− mice were injected with collagenase and FL-, K104A-, or K104Stop-CCL2. The water content was calculated at 1, 3 and 7dpi. Data are shown as mean±SD (n=3). | ||||
|---|---|---|---|---|
| Treatment (time post ICH) | Water content (%) | |||
| Contralateral | Ipsilateral | Cerebellum | ||
| FL CCL2 | Day 1 | 76.63±0.27 | 78.52±0.30 | 74.63±0.23 |
| Day 3 | 76.56±0.33 | 78.45±0.34 | 74.67±0.04 | |
| Day 7 | 76.57±0.34 | 77.20±0.28* | 74.58±0.22 | |
| K104A CCL2 | Day 1 | 76.45±0.34 | 77.24±0.26# | 74.63±0.33 |
| Day 3 | 76.35±0.26 | 77.34±0.29# | 74.66±0.09 | |
| Day 7 | 76.51±0.30 | 78.64±0.24*,# | 74.60±0.23 | |
| K104Stop CCL2 | Day 1 | 76.73±0.21 | 80.11±0.70# | 74.60±0.10 |
| Day 3 | 76.73±0.50 | 77.25±0.06*,# | 74.63±0.25 | |
| Day 7 | 76.37±0.25 | 77.03±0.09* | 74.63±0.12 | |