Table 1. Overall Effects for the SFC Data.
| Group effect | Group × stimulus effect | |
|---|---|---|
| Short-term social fear (Figure 1) | ||
| SFC (day 1) | T(24)=0.89, p=0.38 | |
| Extinction (day 2) | F(1,24)=13.699, p=0.001* | F(8,192)=8.962, p<0.001* |
| Extinction recall (day 3) | F(1,24)=0.918, p=0.348 | F(5,120)=1.639, p=0.155 |
| Long-term social fear (Figure 2) | ||
| SFC (day 1) | T(16)=0.08, p=0.94 | |
| Extinction (day 15) | F(1,16)=10.726, p=0.005* | F(8,128)=4.406, p<0.001* |
| Extinction recall (day 16) | F(1,16)=4.593, p=0.048* | F(5,80)=1.367, p=0.245 |
| Specificity of the induced social fear (Figure 3) | ||
| General anxiety | T(14)=0.84, p=0.42 | |
| Depressive-like behavior | T(14)=−0.70, p=0.50 | |
| EPM locomotion | T(14)=−0.19, p=0.86 | |
| Home cage locomotion | F(1,12)<0.001, p=0.99 | |
| Fear of novelty (Figure 4) | ||
| SFC (day 1) | T(14)=0.43, p=0.67 | |
| Extinction (day 2) | F(1,14)=6.544, p=0.023* | F(8,112)=11.085, p<0.001* |
| Foot-shock exposure (Figure 5) | F(1,14)=1.105, p=0.311 | F(8,112)=0.327, p=0.954 |
| Short-term social fear by diazepam (Figure 6) | ||
| SFC (day 1) | F(3,36)=0.01, p=0.99 | |
| Extinction (day 2) | F(3,36)=7.677, p<0.001* | F(24,288)=4.139, p<0.001* |
| Extinction recall (day 3) | F(3,36)=1.070, p=0.374 | F(15,180)=1.005, p=0.452 |
| Long-term social fear by paroxetine (Figure 7) | ||
| SFC (day 1) | F(3,28)=0.32, p=0.81 | |
| Extinction (day 15) | F(3,28)=32.015, p<0.001* | F(24,224)=8.131, p<0.001* |
| Extinction recall (day 16) | F(3,28)=4.951, p=0.007* | F(15,140)=2.048, p=0.016* |
Abbreviations: EPM, elevated plus maze; SFC, social fear conditioning.
Stimulus effect refers to both non-social and social stimuli during extinction, while during extinction recall it refers to social stimuli only. Student's t-tests, one-way or two-way ANOVA for repeated measures followed by Bonferroni's post-hoc test. *p<0.05.