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. Author manuscript; available in PMC: 2012 Apr 17.
Published in final edited form as: Chembiochem. 2010 Nov 9;12(2):281–289. doi: 10.1002/cbic.201000434

Figure 1.

Figure 1

Crystal structure of Sir2Tm (PDB: 2H4F)[34] displaying the acetyl lysine poised for attack on C1' of the ribose ring of NAD+. Also highlighted is the conserved histidine residue proposed to act as the catalytic base in the second step of the mechanism.[25b]