Abstract
Bacterial endocarditis was produced by intravenous injection of Streptococcus viridans into rabbits with preexisting sterile endocardial vegetations. After 6 h had elapsed, bacteria in the vegetations could not be eradicated by brief treatment with antimicrobials to which the streptococci were sensitive. However, when treatment with penicillin was continued for 4 days, the animals were cured. The 6-h infection therefore offered a model in which treatments could be conveniently compared over a short period. Synergism was demonstrated between penicillin and streptomycin in endocarditis due to a fully penicillin-sensitive streptococcus, a point which had not been previously proved in vivo. The clinical implications are discussed.
Full text
PDF![829](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4762/333064/45cc6b50f5ca/jcinvest00640-0172.png)
![830](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4762/333064/c87b96736bb2/jcinvest00640-0173.png)
![831](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4762/333064/59df510c576e/jcinvest00640-0174.png)
![832](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4762/333064/8212d12d9fb1/jcinvest00640-0175.png)
![833](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4762/333064/c05007221855/jcinvest00640-0176.png)
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Durack D. T., Beeson P. B. Experimental bacterial endocarditis. I. Colonization of a sterile vegetation. Br J Exp Pathol. 1972 Feb;53(1):44–49. [PMC free article] [PubMed] [Google Scholar]
- Durack D. T., Beeson P. B., Petersdorf R. G. Experimental bacterial endocarditis. 3. Production and progress of the disease in rabbits. Br J Exp Pathol. 1973 Apr;54(2):142–151. [PMC free article] [PubMed] [Google Scholar]
- Durack D. T., Petersdorf R. G. Chemotherapy of experimental streptococcal endocarditis. I. Comparison of commonly recommended prophylactic regimens. J Clin Invest. 1973 Mar;52(3):592–598. doi: 10.1172/JCI107220. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GARROD L. P. The bactericidal action of streptomycin. Br Med J. 1948 Feb 28;1(4547):382–386. doi: 10.1136/bmj.1.4547.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GERACI J. E. The antibiotic therapy of bacterial endocarditis: therapeutic data on 172 patients seen from 1951 through 1957: additional observations on short-term therapy (two weeks) for penicillin-sensitivie streptococcal endocarditis. Med Clin North Am. 1958 Jul;42(4):1101–1140. doi: 10.1016/s0025-7125(16)34262-6. [DOI] [PubMed] [Google Scholar]
- Garrison P. K., Freedman L. R. Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart. Yale J Biol Med. 1970 Jun;42(6):394–410. [PMC free article] [PubMed] [Google Scholar]
- HALL B., DOWLING H. F., KELLOW W. Successful short-term therapy of streptococcal endocarditis with penicillin and streptomycin. Am J Med Sci. 1955 Jul;230(1):73–81. doi: 10.1097/00000441-195507000-00012. [DOI] [PubMed] [Google Scholar]
- HUNTER T. H. The treatment of some bacterial infections of the heart and pericardium. Bull N Y Acad Med. 1952 Apr;28(4):213–228. [PMC free article] [PubMed] [Google Scholar]
- Tan J. S., Kaplan S., Terhune C. A., Jr, Hamburger M. Successful two-week treatment schedule for penicillin-susceptible streptococcus viridans endocarditis. Lancet. 1971 Dec 18;2(7738):1340–1343. doi: 10.1016/s0140-6736(71)92360-9. [DOI] [PubMed] [Google Scholar]