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. 1974 Apr;53(4):1178–1184. doi: 10.1172/JCI107656

Lung Volumes in Diffuse Obstructive Pulmonary Syndromes

A C Young 1,2,3, C J Martin 1,2,3, S Tsunoda 1,2,3
PMCID: PMC333104  PMID: 4815081

Abstract

Lung volumes in irreversible diffuse obstructive pulmonary syndromes (DOPSI) have been studied by using an analog of the lung that simulates an 18-breath nitrogen washout. The functional residual capacity (FRC), the dead space volume (Vd), the distribution of ventilation, as well as the pattern of lung emptying have been measured in normal subjects and those with obstructive syndromes. The Vd increased progressively with severity of the obstructive syndrome, as did FRC. For all subjects, both normal and obstructed, the ratio of Vd/FRC remained relatively fixed with the regression line of Vd upon FRC showing a minimal value for Vd of 67 cm3. Vd increased by an average value of 33 cm3 per liter of lung volume above this value. The increase in FRC resulted from the increased volume of the poorly ventilated compartment for the most part. X-ray evidence of emphysema was poorly correlated with the changes in Vd or FRC. A significant increase in anatomical Vd in DOPSI makes up an appreciable portion of the total Vd (physiological).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARTELS J., SEVERINGHAUS J. W., FORSTER R. E., BRISCOE W. A., BATES D. V. The respiratory dead space measured by single breath analysis of oxygen, carbon dioxide, nitrogen or helium. J Clin Invest. 1954 Jan;33(1):41–48. doi: 10.1172/JCI102868. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BATEMAN J. B. Studies of lung volume and intrapulmonary mixing. Nitrogen clearance curves: apparent respiratory dead space and its significance. J Appl Physiol. 1950 Sep;3(3):143–160. doi: 10.1152/jappl.1950.3.3.143. [DOI] [PubMed] [Google Scholar]
  3. Darling R. C., Cournand A., Richards D. W. STUDIES ON THE INTRAPULMONARY MIXTURE OF GASES. III. AN OPEN CIRCUIT METHOD FOR MEASURING RESIDUAL AIR. J Clin Invest. 1940 Jul;19(4):609–618. doi: 10.1172/JCI101163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FOWLER W. S., CORNISH E. R., Jr, KETY S. S. Lung function studies. VIII. Analysis of alveolar ventilation by pulmonary N2 clearance curves. J Clin Invest. 1952 Jan;31(1):40–50. doi: 10.1172/JCI102575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FOWLER W. S. Lung function studies. V. Respiratory dead space in old age and in pulmonary emphysema. J Clin Invest. 1950 Nov;29(11):1439–1444. doi: 10.1172/JCI102383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. GOLDSMITH J. R. A simple test of maximal expiratory flow for detecting ventilatory obstruction. Am Rev Tuberc. 1958 Aug;78(2):180–190. doi: 10.1164/artpd.1958.78.2.180. [DOI] [PubMed] [Google Scholar]
  7. HICKAM J. B., FRAYSER R. A comparative study of intrapulmonary gas mixing and functional residual capacity in pulmonary emphysema, using helium and nitrogen as the test gases. J Clin Invest. 1958 Apr;37(4):567–573. doi: 10.1172/JCI103639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hogg J. C., Nepszy S. J., Macklem P. T., Thurlbeck W. M. Elastic properties of the centrilobular emphysematous space. J Clin Invest. 1969 Jul;48(7):1306–1312. doi: 10.1172/JCI106097. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hughes J. M., Hoppin F. G., Jr, Mead J. Effect of lung inflation on bronchial length and diameter in excised lungs. J Appl Physiol. 1972 Jan;32(1):25–35. doi: 10.1152/jappl.1972.32.1.25. [DOI] [PubMed] [Google Scholar]
  10. Klingele T. G., Staub N. C. Terminal bronchiole diameter changes with volume in isolated, air-filled lobes of cat lung. J Appl Physiol. 1971 Feb;30(2):224–227. doi: 10.1152/jappl.1971.30.2.224. [DOI] [PubMed] [Google Scholar]
  11. La Force R. C., Lewis B. M. Diffusional transport in the human lung. J Appl Physiol. 1970 Mar;28(3):291–298. doi: 10.1152/jappl.1970.28.3.291. [DOI] [PubMed] [Google Scholar]
  12. MARTIN H. B., PROCTOR D. F. Pressure-volume measurements on dog bronchi. J Appl Physiol. 1958 Nov;13(3):337–343. doi: 10.1152/jappl.1958.13.3.337. [DOI] [PubMed] [Google Scholar]
  13. Meneely G. R., Kaltreider N. L. THE VOLUME OF THE LUNG DETERMINED BY HELIUM DILUTION. DESCRIPTION OF THE METHOD AND COMPARISON WITH OTHER PROCEDURES. J Clin Invest. 1949 Jan;28(1):129–139. doi: 10.1172/JCI102041. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. NUNN J. F., CAMPBELL E. J., PECKETT B. W. Anatomical subdivisions of the volume of respiratory dead space and effect of position of the jaw. J Appl Physiol. 1959 Mar;14(2):174–176. doi: 10.1152/jappl.1959.14.2.174. [DOI] [PubMed] [Google Scholar]
  15. Paiva M. Gas transport in the human lung. J Appl Physiol. 1973 Sep;35(3):401–410. doi: 10.1152/jappl.1973.35.3.401. [DOI] [PubMed] [Google Scholar]
  16. Read J., Lee J. Effect of changes of tidal volume on dead space in obstructive lung disease. J Appl Physiol. 1969 Jan;26(1):105–110. doi: 10.1152/jappl.1969.26.1.105. [DOI] [PubMed] [Google Scholar]
  17. Suda Y., Martin C. J., Young A. C. Regional dispersion of volume-to-ventilation ratios in the lung of man. J Appl Physiol. 1970 Oct;29(4):480–485. doi: 10.1152/jappl.1970.29.4.480. [DOI] [PubMed] [Google Scholar]
  18. Sugihara T., Martin C. J., Hildebrandt J. Length-tension properties of alveolar wall in man. J Appl Physiol. 1971 Jun;30(6):874–878. doi: 10.1152/jappl.1971.30.6.874. [DOI] [PubMed] [Google Scholar]
  19. Tsunoda S., Young A. C., Martin C. J. Emptying pattern of lung compartments in normal man. J Appl Physiol. 1972 May;32(5):644–649. doi: 10.1152/jappl.1972.32.5.644. [DOI] [PubMed] [Google Scholar]
  20. YOUNG A. C. Dead space at rest and during exercise. J Appl Physiol. 1955 Jul;8(1):91–94. doi: 10.1152/jappl.1955.8.1.91. [DOI] [PubMed] [Google Scholar]

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