Abstract
Nimbidin, the crude bitter compound from neem has been investigated for its gastric anti secretory activity in rats and cats. It exhibited significant anti – secretory activity in pylorus ligated rats and cats. In lumen – perfused rats it suppressed the basal as well as histamine and carbachol stimulated gastric acid output at 40 mg/kg (i.v). However it had no effect on ASA – induced back – diffusion of H+ ions. This anti secretory activity of nimbidin was found to be similar to that of H2 – receptor antagonists, which are reported to suppress the histamine induced gastric secretion in animals and man.
KEY WORDS: Azadirachta indica, Nimbidin, Pylorus – ligated rats, Stomach – lumen perfused rats, Pylorus – ligated cats, H2 – receptor blockade
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