Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1976 Jul;58(1):1–6. doi: 10.1172/JCI108438

Effect of growth hormone-release inhibiting hormone on hormones stimulating exocrine pancreatic secretion.

S J Konturek, J Tasler, W Obtulowicz, D H Coy, A V Schally
PMCID: PMC333148  PMID: 932201

Abstract

The nature and extent of growth hormone-release inhibiting hormone (GH-RIH, somatostatin)-induced inhibition of pancreatic secretion of bicarbonate and protein, an index of enzyme secretion, were studied by administration of exogenous secretin or cholecystokinin (CCK) and of a number of stimulants for endogenous release of these hormones in fasted pancreatic fistula dogs with and without an infusion of GH-RIH. The results of this study show that GH-RIH inhibits the pancreatic fluid and bicarbonate secretion induced by duodenal acidification and exogenous secretion. The kinetic analysis shows that the interaction between GH-RIH and secretin affecting pancreatic bicarbonate secretion possesses the characteristics of competitive inhibition. GH-RIH does not change the pancreatic protein response to exogenous CCK, but profoundly inhibits pancreatic response to a variety of the endogenous stimulants of CCK release, including duodenal perfusion of sodium oleate, amino acid mixture, or feeding of a peptone meal. We conclude that GH-RIH is a very potent inhibitor of the endogenous release of CCK from the intestinal mucosa and inhibits competitively the action of secretin but not CCK on the exocrine pancreatic secretion.

Full text

PDF
1

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barbezat G. O., Grossman M. I. Release of cholecystokinin by acid (38562). Proc Soc Exp Biol Med. 1975 Feb;148(2):463–467. doi: 10.3181/00379727-148-38562. [DOI] [PubMed] [Google Scholar]
  2. Barros D'Sa A. A., Bloom S. R., Baron J. H. Direct inhibition of gastric acid by growth-hormone release-inhibiting hormone in dogs. Lancet. 1975 Apr 19;1(7912):886–887. doi: 10.1016/s0140-6736(75)91685-2. [DOI] [PubMed] [Google Scholar]
  3. Bloom S. R., Mortimer C. H., Thorner M. O., Besser G. M., Hall R., Gomez-Pan A., Roy V. M., Russell R. C., Coy D. H., Kastin A. J. Inhibition of gastrin and gastric-acid secretion by growth-hormone release-inhibiting hormone. Lancet. 1974 Nov 9;2(7889):1106–1109. doi: 10.1016/s0140-6736(74)90869-1. [DOI] [PubMed] [Google Scholar]
  4. Boden G., Sivitz M. C., Owen O. E., Essa-Koumar N., Landor J. H. Somatostatin suppresses secretin and pancreatic exocrine secretion. Science. 1975 Oct 10;190(4210):163–165. doi: 10.1126/science.1166308. [DOI] [PubMed] [Google Scholar]
  5. Brazeau P., Vale W., Burgus R., Ling N., Butcher M., Rivier J., Guillemin R. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science. 1973 Jan 5;179(4068):77–79. doi: 10.1126/science.179.4068.77. [DOI] [PubMed] [Google Scholar]
  6. Chideckel E. W., Palmer J., Koerker D. J., Ensinck J., Davidson M. B., Goodner C. J. Somatostatin blockade of acute and chronic stimuli of the endocrine pancreas and the consequences of this blockade on glucose homeostasis. J Clin Invest. 1975 Apr;55(4):754–762. doi: 10.1172/JCI107986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Coy D. H., Coy E. J., Arimura A., Schally A. V. Solid phase synthesis of growth hormone-release inhibiting factor. Biochem Biophys Res Commun. 1973 Oct 15;54(4):1267–1273. doi: 10.1016/0006-291x(73)91124-8. [DOI] [PubMed] [Google Scholar]
  8. DOWD J. E., RIGGS D. S. A COMPARISON OF ESTIMATES OF MICHAELIS-MENTEN KINETIC CONSTANTS FROM VARIOUS LINEAR TRANSFORMATIONS. J Biol Chem. 1965 Feb;240:863–869. [PubMed] [Google Scholar]
  9. Debas H. T., Grossman M. I. Pure cholecystokinin: pancreatic protein and bicarbonate response. Digestion. 1973;9(6):469–481. doi: 10.1159/000197476. [DOI] [PubMed] [Google Scholar]
  10. Dembiński A., Konturek S. J., Thor P. The role of vagal innervation in gastric and pancreatic responses to meals varying in pH. J Physiol. 1974 Sep;241(3):677–688. doi: 10.1113/jphysiol.1974.sp010677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Fordtran J. S., Walsh J. H. Gastric acid secretion rate and buffer content of the stomach after eating. Results in normal subjects and in patients with duodenal ulcer. J Clin Invest. 1973 Mar;52(3):645–657. doi: 10.1172/JCI107226. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Grossman M. I., Konturek S. J. Gastric acid does drive pancreatic bicarbonate secretion. Scand J Gastroenterol. 1974;9(3):299–302. [PubMed] [Google Scholar]
  13. Hall R., Besser G. M., Schally A. V., Coy D. H., Evered D., Goldie D. J., Kastin A. J., McNeilly A. S., Mortimer C. H., Phenekos C. Action of growth-hormone-release inhibitory hormone in healthy men and in acromegaly. Lancet. 1973 Sep 15;2(7829):581–584. doi: 10.1016/s0140-6736(73)92413-6. [DOI] [PubMed] [Google Scholar]
  14. Herrera F., Kemp D. R., Tsukamoto M., Woodward E. R., Dragstedt L. R. A new cannula for the study of pancreatic function. J Appl Physiol. 1968 Aug;25(2):207–209. doi: 10.1152/jappl.1968.25.2.207. [DOI] [PubMed] [Google Scholar]
  15. Mortimer C. H., Tunbridge W. M., Carr D., Yeomans L., Lind T., Coy D. H., Bloom S. R., Kastin A., Mallinson C. N., Besser G. M. Effects of growth-hormone release-inhibiting hormone on circulating glucagon, insulin, and growth hormone in normal, diabetic, acromegalic, and hypopituitary patients. Lancet. 1974 Apr 20;1(7860):697–701. doi: 10.1016/s0140-6736(74)92903-1. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES