Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1976 Aug;58(2):493–499. doi: 10.1172/JCI108493

Regulation of pancreatic and gallbladder functions by intraluminal fatty acids and bile acids in man.

J R Malagelada, E P DiMagno, W H Summerskill, V L Go
PMCID: PMC333204  PMID: 956380

Abstract

The effects of intraduodenal glycerol, fatty acid (FA) chain length and FA loads, and bile acid (BA) concentrations on pancreatic and gallbladder function were investigated in 31 healthy volunteers by a perfusion method. FA absorption rates in the duodenum and proximal jejunum were measured simultaneously. Pancreatic and gallbladder responses were augmented by increasing FA chain length and FA loads until the "maximal" secretory capacity of the pancreas and gallbladder emptying was attained. Glycerol had no effect. Raising BA concentrations above the critical micellar concentration accelerated FA absorption rates but decreased the magnitude of pancreatic and gallbladder responses to FA. Higher BA concentrations exerted an opposite effect, slowing FA absorption and increasing pancreatic and gallbladder responses. Indeed, a significant, inverse correlation was found between FA absorption and pancreatic and gallbladder responses to FA, suggesting a relationship between the length of intestine exposed to FA and the amount of cholecystokinin (and/or other neurohormonal factors) released, which stimulates pancreatic secretion and gallbladder contraction.

Full text

PDF
493

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ammon H. V., Thomas P. J., Phillips S. F. Effects of oleic and ricinoleic acids on net jejunal water and electrolyte movement. Perfusion studies in man. J Clin Invest. 1974 Feb;53(2):374–379. doi: 10.1172/JCI107569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BENNETT S. INTESTINAL ABSORPTIVE CAPACITY AND SITE OF ABSORPTION OF FAT UNDER STEADY STATE CONDITIONS IN THE UNANAESTHETIZED RAT. Q J Exp Physiol Cogn Med Sci. 1964 Apr;49:210–218. doi: 10.1113/expphysiol.1964.sp001721. [DOI] [PubMed] [Google Scholar]
  3. BORGSTROM B., DAHLQVIST A., LUNDH G., SJOVALL J. Studies of intestinal digestion and absorption in the human. J Clin Invest. 1957 Oct;36(10):1521–1536. doi: 10.1172/JCI103549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cohen M., Morgan R. G., Hofmann A. F. One-step quantitative extraction of medium-chain and long-chain fatty acids from aqueous samples. J Lipid Res. 1969 Sep;10(5):614–616. [PubMed] [Google Scholar]
  5. DiMagno E. P., Go V. L., Summerskill H. J. Intraluminal and postabsorptive effects of amino acids on pancreatic enzyme secretion. J Lab Clin Med. 1973 Aug;82(2):241–248. [PubMed] [Google Scholar]
  6. Go V. L., Hofmann A. F., Summerskill W. H. Pancreozymin bioassay in man based on pancreatic enzyme secretion: potency of specific amino acids and other digestive products. J Clin Invest. 1970 Aug;49(8):1558–1564. doi: 10.1172/JCI106373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Go V. L., Hofmann A. F., Summerskill W. H. Simultaneous measurements of total pancreatic, biliary, and gastric outputs in man using a perfusion technique. Gastroenterology. 1970 Mar;58(3):321–328. [PubMed] [Google Scholar]
  8. Go V. L., Poley J. R., Hofmann A. F., Summerskill W. H. Disturbances in fat digestion induced by acidic jejunal pH due to gastric hypersecretion in man. Gastroenterology. 1970 May;58(5):638–646. [PubMed] [Google Scholar]
  9. Hoffman N. E., Hofmann A. F. A comparison of the rate of absorption micellar and nonmicellar oleic acid. A jejunal perfusion study in man. Am J Dig Dis. 1973 Jun;18(6):489–492. doi: 10.1007/BF01076599. [DOI] [PubMed] [Google Scholar]
  10. Malagelada J. R., Go V. L., DiMagno E. P., Summerskill W. H. Interactions between intraluminal bile acids and digestive products on pancreatic and gallbladder function. J Clin Invest. 1973 Sep;52(9):2160–2165. doi: 10.1172/JCI107400. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Malagelada J. R., Go V. L., Summerskill W. H. Differing sensitivities of gallbladder and pancreas to cholecystokinin-pancreozymin (CCK-PZ) in man. Gastroenterology. 1973 May;64(5):950–954. [PubMed] [Google Scholar]
  12. Malagelada J. R., Pihl O., Linscheer W. G. Impaired absorption of micellar long-chain fatty acid in patients with alcoholic cirrhosis. Am J Dig Dis. 1974 Nov;19(11):1016–1020. doi: 10.1007/BF01255783. [DOI] [PubMed] [Google Scholar]
  13. Meyer J. H., Jones R. S. Canine pancreatic responses to intestinally perfused fat and products of fat digestion. Am J Physiol. 1974 May;226(5):1178–1187. doi: 10.1152/ajplegacy.1974.226.5.1178. [DOI] [PubMed] [Google Scholar]
  14. Whalen G. E., Harris J. A., Geenen J. E., Soergel K. H. Sodium and water absorption from the human small intestine. The accuracy of the perfusion method. Gastroenterology. 1966 Dec;51(6):975–984. [PubMed] [Google Scholar]
  15. Withington R., Collett J. H. The transfer of salicylic acid across a cellophane membrane from micellar solutions of polysorbates 20 and 80. J Pharm Pharmacol. 1973 Apr;25(4):273–280. doi: 10.1111/j.2042-7158.1973.tb10007.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES