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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Traffic. 2012 Jan 31;13(4):586–598. doi: 10.1111/j.1600-0854.2011.01326.x

Figure 4. Model for Sna3 function and sorting.

Figure 4

A) Rsp5 is recruited to Mup1 in response to high levels of methionine through interaction with the Art1 adaptor protein. This association with Rsp5 results in the ubiquitination of Art1.

B) Mup1 is also internalized in response to nutrient stress, where Rsp5 can be recruited to Mup1 via Sna3, which can act as a complementary adaptor protein. There is partial redundancy between Art1 and Sna3, each of which contributes to MVB sorting. Sna3 can also be ubiquitinated by Rsp5.

C) A lysineless version of Sna3 (cytosolic lysine to arginine mutations), which can still associate with both Rsp5 and Mup1, fosters ubiquitination of Mup1 and uses Mup1~Ub to enter the MVB pathway.