Fig. 3.

Effects of interleukin-1 receptor antagonist (IL-1ra), fluoxetine (FLX), and their combination on the outcome of the combined dexamethasone (DEX)/corticotrophin-releasing hormone (CRH) test. Sample sizes: naïve n = 9; control n = 12; IL-1ra n = 9; FLX n = 8; IL-1ra + FLX n = 8. Data are shown as mean ± SEM. *p < 0.05 versus naïve; ^†p < 0.05 versus SE alone; ^‡p < 0.05 versus IL-1ra alone; ^§p < 0.05 versus FLX alone (two-way repeated measures analysis of variance + Bonferroni post hoc test). DEX significantly suppressed plasma CORT only in naïve animals, and CRH significantly increased plasma corticosterone (CORT) in all groups (one-way repeated measures analysis of variance + Bonferroni post hoc test). SE = status epilepticus