Table 1.
Summary of Effects of IL-1ra, Fluoxetine and Their Combination on Epilepsy-Associated Depression-Like Impairments
| Groups | Naive | Post-SE | |||
|---|---|---|---|---|---|
| Parameters | Control | IL-1ra | Fluoxetine | IL-1ra + fluoxetine | |
| Increased immobility time in the FST | − | +++ | ++ | +++ | − |
| Lack of saccharin preference | − | +++ | − | +++ | − |
| HPA axis function | + | +++ | ++ | +++ | ++ |
| Serotonergic tone | +++ | + | ++ | + | ++++ |
| Presynaptic 5-HT1A function | ++ | ++++ | +++ | ++++ | + |
Behavioral, neuroendocrine, biochemical, and receptor impairments in post-SE animals without (control) and with treatments are compared to normal values observed in naïve animals
FST = forced swim test; HPA = hypothalamo-pituitary-adrenocortical; IL-1ra = interleukin-1 receptor antagonist; SE = status epilepticus