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. 1991 Feb 25;19(4):783–787. doi: 10.1093/nar/19.4.783

Repression by Jun of the Polyoma-virus enhancer overrides activation in a cell specific manner.

J Schneikert 1, J L Imler 1, B Wasylyk 1
PMCID: PMC333711  PMID: 1850124

Abstract

The activities of promoters and enhancers are generated by the combinatorial effects of the factors which interact with them. The Polyoma virus (Py) enhancer contains sequences that are positively regulated by the proto-oncogene Jun. Surprisingly, Jun has an additional and overriding repressing effect on enhancer activity, which is cell specific. Thus overall enhancer activity cannot be simply deduced from the properties of individual elements. We present evidence that repression is indirect.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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